For the chance to visit the Colosseum, the Pantheon, the Spanish Steps and the Trevi Fountain compare your flights from Manchester to Rome today! A direct flight to Rome lasts just 2 hours 40 minutes, however the cheapest airline tickets to Rome is generally found on flights with one or two stopovers. Ryanair is the airline known to advertise the best flight discounts from Manchester to Rome in the past with the price of Rome air tickets dropping right down to just over £50 in January. Nevertheless, KLM, Lufthansa, Swiss and Air France are but a few more airlines that fly from Manchester and offer low cost deals to Rome. The simplest way to find budget airline tickets is using a flight comparison tool. There are two airports in Rome which are both well-connected to the city centre by bus, taxi or train. The journey will take between 20-45 minutes.