The 107 guestrooms at the Dylan are all decorated in exactly the same manner and share identical amenities. The differences come in how high up they are positioned in the building and their surface area, with the larger rooms having a separate seating area. The rooms are spacious and all have high ceilings which usually make for characteristic rooms - the only problem here is that the rooms are too empty leaving a hollow feeling. They are all upholstered with a grey-blue carpet and have matching curtains and bed plaids, while the armchairs and sofas are a light olive green colour. The floating bedside tables have a telephone and iPod docking station while other furniture includes a desk and chair and a drawer unit on top of which is a 27" flatscreen television. Every room has a feature wall painted in sky blue in contrast to the other three white-washed walls but sadly there is very little in the way of artwork, something that would help fill the void. Other amenities include a minibar and snack try (which also boasts such things as a first aid kit and intimacy kit, safe, robes, iron and ironing board and tea and coffee facilities. The bathrooms are fitted in black veined white Carrera marble and have large walk-in showers, toiletries and a hairdryer. In honour of the building's former occupants, the glasses at the sink are actually beakers and the soap dish is in fact a petri dish!
By far and away the most impressive room is the alchemy suite. With stone walls, a beautiful vaulted ceiling and stained glass windows, it is unlike any other room in the city. Although not the biggest, it is the sole room in the hotel with any character and its bathroom, like all the suites, has both a walk-in shower and bathtub.